Medical three-in-one filter, washing and drying machine Telmisartan refining and purification multifunctional equipment

In the clinical trials of treating mild and moderate essential hypertension, telmisartan has a significant effect, and can effectively reduce systolic and diastolic blood pressure. In different clinical trials, clinical comparisons were carried out with placebo, calcium antagonists, β-blockers and angiotensin transferase inhibitors, etc., and the results found that telmisartan has similar or more significant effects, and its overall The curative effect is higher than that of sartan drugs such as losartan which were listed earlier. It not only effectively reduces the average pressure during the day and night for 24 hours, but also effectively controls the sudden symptoms of high blood pressure in the morning.

In patients with mild and moderate hypertension, the combination of 40~80mg telmisartan and 12.5mg hydrochlorothiazide is more effective than single medication.

Telmisartan has been widely affirmed and accepted by clinicians and patients after it was launched on the market. In just a few years, its sales have soared and it has become a new force in the treatment of hypertension.

However, the traditional route of producing the drug has low yield and complicated operation, which is not conducive to cost reduction, and three wastes pollution occurs, which causes relatively large pollution to the environment. Wuxi ZhangHua Machinery Co., Ltd. has carried out a lot of design and development work, and finally successfully developed the SR-tubular-cone reaction filtration and drying multifunctional machine, the invention patent number: ZL 20172 1560677.6. Realized a major breakthrough in the filtration, washing and drying equipment of telmisartan raw materials Breakthrough, and reached a strategic partnership with well-known pharmaceutical companies, making outstanding contributions to the quality of anti-hypertensive raw material medicine equipment.

Telmisartan refining and purification multifunctional equipment Medical three-in-one filtration washing and drying process:

(1) First seal the entire unit system, fill it with sterile inert gas (such as N2 gas) for protection, add crystallization liquid to be processed from the crystallizer to the "three-in-one" through the automatic valve, and close the feed valve after reaching a certain volume.

(2) Pass in inert gas to pressurize, and realize the solid-liquid separation of the crystallization liquid through the large metal filter plate at the bottom.

(3) After the solid-liquid separation of the crystallization solution, spray and wash the filter cake.

(4) After washing, the stirring device is lowered by the hydraulic device for stirring, and at the same time, the heating pipeline system inside the stirring is used to heat the material layer, and the temperature of the drying process is strictly controlled, otherwise the degradation and failure of the drug will be caused.

While heating and drying, vacuumize the system to make the solvent evaporate quickly, and at the same time start the dust collector to work automatically to ensure the normal ventilation of the vacuum system.

(5) After the material layer is dried and qualified (sampling test or automatic process analysis can be used), stop the vacuum and enter the automatic discharge program.

(6) Automatic discharge: lower the stirring device, control the stirring speed and the descending speed of the stirring blade to carry out the scraping and feeding action, so that the powdery material can quickly enter the silo through the discharge valve, and stop when the stirring is close to the metal filter plate layer Stir and descend, and then inject inert gas instantly to blow all the bottom materials to the silo.

Telmisartan refining and purification multifunctional equipment Medical three-in-one filter washing and drying Advantages and features:

Putting multiple processes such as washing, filtering, and drying in one airtight device to complete multiple operations reduces the risk of pollution transferred between different devices. Protective gases such as N2 can also be passed through the device to isolate contact with the external environment, greatly improving The probability of product contamination is reduced, which is conducive to the guarantee of product sterility.

1. Online CIP and SIP can be realized, which is convenient for cleaning and sterilization or cleaning and sterilization after disassembly

The current "three-in-one" equipment has changed the shortcomings of the original centrifugation, filtration or oven that are not suitable for online cleaning and sterilization; by installing spray balls, connecting pure steam, etc., and adding cleaning solvents when necessary, the equipment can be realized without disassembly Automatically complete the cleaning and sterilization functions under certain circumstances, providing equipment guarantee for aseptic production. The "three-in-one" equipment packaged separately is currently able to achieve CIP and SIP in some foreign countries, but it is still not possible in China, and most of them are cleaned and sterilized after disassembly.

2. Pollution-free sampling can be realized

Most of the "three-in-one" equipment is designed with a safe and pollution-free sampling valve device. When sampling, it is not necessary to open the equipment cover or cabinet door, which avoids the contamination of drugs by impurities brought into the sampling tool.

3. Improve production efficiency and save operating costs

(1) Since the work completed by multiple equipment operations in multiple processes is completed by one equipment, the operation time is reduced and the production cycle is shortened; (2) The space occupied by the clean area is saved on site, and construction costs are reduced; (3) Also It saves operating costs such as air conditioning and refrigeration, and has certain effects on reducing costs, increasing efficiency, and saving energy.

4. Saving labor costs, but also conducive to stable product quality

The production process is reduced, the degree of automation is improved, the labor force is reduced, and the error and pollution probability in the operation of the staff are also reduced, which is conducive to the uniform and stable quality of the drug batches.

5. In line with the development trend of cleaner production in the world

The fully enclosed production process in pharmaceutical production has always been the best production method pursued by pharmaceutical manufacturers. In this way, the pharmaceutical production process is not affected by external or artificial impurities, pollution, etc., and the quality of pharmaceuticals can be guaranteed most effectively, and Production also has minimal environmental impact. This production method is in line with the development trend of cleaner production in the world.

The design and selection of "three-in-one" equipment mainly considers product characteristics, process routes, and GMP. Manufacturing pharmaceuticals is an ideal situation.

Therefore, you should also pay attention to how to choose the integrated equipment according to the characteristics of the production process: generally speaking, the above two equipments are not suitable for use when the product is relatively viscous or when crushing materials that become viscous when heated; special crystal materials cannot be used when they cannot be stirred. An all-in-one machine with stirring; materials with heat sensitivity or low temperature requirements can be cooled or vacuumed to cooperate with drying, and can basically be used to improve product quality.

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