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Introduction of ANFD series Agitated Nutsche Filter Dryer

July 16, 2023

  The traditional process applied in the production of APIs: crystallize in the tank → separate solid and liquid by centrifuge → wash crystals with detergent → separate solid and liquid → manually discharge materials → load on the plate → dry by the double-cone (or vacuum drying box) → manually discharge materials → load into raw materials barrels. Such a traditional process can no longer meet the requirements of GMP for drug production.


Agitated Nutsche Filter Dryer

  ANFD series Agitated Nutsche Filter Dryer integrates the three processes (including filtration, washing and drying) into one piece. It is airtight, highly automated, easy to operate, high recovery benefit, and complete safety measures, which greatly reduces the labor force. This product also has the following features:

          The whole production process can be completed by the system, from feeding crystals and solid-liquid suspension to automatic discharge of raw materials after drying in a fully closed condition. It can stir solid-liquid, clean filter cake, filter, remove liquid, dry, discharge, and complete CIP/SIP, in line with GMP requirements.

          As the production is carried out in a fully closed condition, the hydraulic motor discharge valve is internally driven by the screw, which can maintain the overall sealing performance of the agitated nutsche filter dryer even when the hydraulic station loses pressure.


The chassis of ANFD Machine



The chassis has a multi-channel sealing structure and leakage observation device with collection function, which can timely detect safety accidents caused by chassis leakage, reduce the occurrence of personnel poisoning and allergy accidents caused by contact with toxic products, and meet EHS requirements.


ANFD series Agitated Nutsche Filter Dryer


In the CIP (cleaning-in-place) process, organic solvents and process water are used to clean the filter cake and tank without disassembling the equipment, to reduce the risk of contamination and cross-contamination to a low level, thus ensuring the safety of the material, workers, and machine of has a delicate taste, delicious taste, nutrition, and health.


CIP process for agitated nutsche filter dryer



About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co., Ltd was founded in 1976, and committed to researching, developing, and manufacturing reaction, crystallization, filtration, and drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration, and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allow us to customize agitated nutsche filter dryers with a diameter of more than four meters, coupled with an imported welding robot, which improves the welding accuracy, appearance, and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic, and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum, and fully automatic equipment, ensuring safe, energy saving and environment-protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met the requirements of the FDA, CGMP, ATEX, and ASME, certified by PED, MD, LVD, MOM, and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in the after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation, and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all its clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration, and drying technology applied on the equipment in pharmaceutical, chemical, and other industries with good reputations.

The discharge valve is designed with special spraying and purging devices, which can purge and clean the valve core and sealing seat without disassembling the valve body, effectively preventing cross-contamination and better protecting the product. In another side, very little organic solvent used for production will volatilize, and almost 100% of the solvent can be recovered, which creates great economic benefits.

         ◎It adopts PLC control system, with the functions of parameter setting, historical trend, formula setting, batch report, etc., which provides rich data information for the production process, as well as strong support for the factory's informationization construction.




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