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what is CN-Conical Filter dryercone filter, washing and drying "three-in-one" equipment in the production of raw m??? |

March 20, 2023
The offered product is widely demanded in the market for its foreseeable application prospects.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
Zhanghua  is known for combining aesthetic functionality and innovation.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
It is mildew resistant. Its coating has a significant effect on increasing the difficulty for future mold growth and spread.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.

In the production process of AIPs, in order to reduce the material loss and avoid environment pollution that may be caused by the material transfer after crystallization, the subsequent filtration, washing and drying processes of the material are usually completed in one single piece of equipment, which is called “Three-in-One” for short or Agitated Nutsche Filter Dryer(ANFD). The most common “Three-in-One” used in drug production is with flat bottom, and there is no doubt that it has advantages in the production of sterile APIs, however, certain defects in another side as well, including small filter area in the circular flat bottom, side discharge (there is always material left behind), poor drying performance, small movement of material during the drying process, and low efficient heat transfer, more limits of drying, etc.

 

1 Basic Structure and Working Principle "

The Conical Filter Dryer can complete a series of processes in one single piece of equipment, including solid-liquid separation and filtration, filter cake washing and material drying processes.

 

1.1 Basic Structure

 

Taking the clean-grade Conical Filter Dryer for the production of APIs as an example, its main structure is shown in Figure 1.








Figure 1 ----Structure of Clean-grade conical filter dryer

a - Dust-proof mechanism   b - Explosion-proof transmission mechanism

c - Rack mechanism      d - Spray mechanism

e - Main shaft to stir and built-in heat exchange system

f - Main body           g - Auxiliary maintenance mechanism

h - Filtering mechanism    i – Automatic downward expansion discharge valve

More details:

a is the dust-proof mechanism, which meets the requirements of the clean area and helps to avoid dust pollution caused by transmission parts.

b is the explosion-proof transmission mechanism, including an explosion-proof main motor and a reducer. Its hardened gear reducer can strengthen the transmission capacity and ensure stable operation of the equipment.

c is the rack mechanism, with clean-grade mechanical seal of main shaft and multi-support layout.

d is the spray mechanism, including components for material washing and CIP.

e is the main shaft to stir and built-in heat exchange system, using a ribbon-type suspended stirring mechanism (no fulcrum at the bottom).

f is the main body of the equipment, including the heat exchange jacket and outer insulation components.

g is the auxiliary maintenance mechanism, which is used to assist the cone parts to go up and down, making it easy for disassembly and maintenance.

h is the filtering mechanism, including components for filtering medium and Reverse CIP (RCIP).

i is an automatic downward expansion discharge valve, which can realize fully automatic operation. It uses a valve cover with flat bottom, no dead corner for accumulated material, and can be completely cleaned in place.

 

1.2 Working principle

 

An intermittent process flow is applied to Wuxi Zhanghua Pharmaceutical Equipment’s Conical Filter Dryer, of which typical operation process is “feeding-filtering-washing-drying-discharging-CIP”, as shown in Figure 2.

 

1.2.1 Filtering

 

The equipment generally adopts either pressure filtration or vacuum filtration, and there is huge difference between these two ways according to the characteristics of materials and filter cakes, which needs to be confirmed by small tests.

 

1.2.2 Drying

During the vacuum drying process, the equipment has a built-in heat medium circulation system. When the heat medium is added, at the same time, with vacuum pumping, the ribbon-type stirring mechanism rotates forward to lift the material for flipping in all the directions to realize the complete heat exchange, and the drying status of materials can be monitored by a vacuum online sampler.

 

1.2.3 Discharge

 

After the drying process is completed and the internal environment of the equipment returns to normal pressure, the discharge valve is opened, and the stirring mechanism rotates forward to discharge most of the materials, and the rest small number of residuals are forced out by the stirring mechanism in reverse.

 

1.2.4 Cleaning

 

After the discharge is completed, the equipment is cleaned in multiple directions: the washing system will clean the inner part and the ribbon-type stirring mechanism; RCIP system will clean the residual layer, filter medium and the valve; CIP system will clean the valve cover and the connecting nozzle. 






Figure 2------ Operation Flow of Conical Filter Dryer

2 Advantages of Wuxi Zhanghua Pharmaceutical Equipment’s Conical Filter Dryer in the Production of APIs

 

The new version of GMP puts forward higher requirements for the production of APIs and related equipment. It is obvious that equipment is the key to ensuring the quality of APIs and their production stability. The following will explain the advantages of Conical Filter Dryer

 in the production of API in combination with the relevant requirements in the new GMP.

 

2.1 High Product Purity

 

2.1.1 No Impurities Allowed to Be Mixed in the Material

 

After the material enters, parts in the equipment that are directly exposed to the material include the functional nozzle, the inner wall, the stirring mechanism, the filtering mechanism, the filtrate channel, the filtering component and the discharge valve mechanism. Among them, except for the stirring mechanism, the others are all static. Equipped by the correct materials, with proper manufacturing process, these parts will not bring any foreign matter into the process. However, the stirring mechanism is moving. First, it needs to use clean-grade mechanical seal of main shaft to realize good sealing performance. An isolation cavity is set in the mechanical seal to prevent any impurities that may be generated by the environment or the mechanical seal itself from entering the equipment. Secondly, as there is no rotating fulcrum at the bottom of Conical Filter Dryer for stirring mechanism, which is designed with suspension concept, it fundamentally eliminates the possibility of contamination by impurities.

 

2.1.2 Ensure the Safe and Clean Environment

 

The equipment is fully sealed, which not only ensures the cleanliness of the product during the process, but also protects the production environment. Especially for cases with volatile or dangerous solutions in the process, the equipment can ensure the safety of the environment and operators.

 

The ribbon-type stirring mechanism uses an axially fixed structure that does not move up and down, and maintains a settled and stable safe distance from the equipment, ensuring production safety without routine maintenance.

 

2.2 Advantages of Adaptability

 

2.2.1 High Filtering Efficiency

 

(1) Large filter area: The filter medium of Conical Filter Dryer is cone-shaped, equipped on the wall of the tank, as shown in Figure 3. Taking the size of the device with an inner diameter of about 1 m as an example, the standard conical filter area is about 1.6 m 2 , and the effective filter area is about three times that of the "Three-in-One" with the same diameter, but flat bottom.



The product, with long-lasting performance and good durability, is of the highest quality.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
The product is highly marketable in world markets and has high commercial value.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
The product is reasonably priced and is favored by many customers and will be widely used in the market.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
Most costumers consider the product has huge market potential and worth of trust.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
By wearing this product, people can look stylish and feel comfortable while staying active either at work or at play.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
It is well-known that Zhanghua has good quality  after-sales service.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
Our  enjoys a longer lifespan than other similar products for its  material.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.
Using this product, manufacturers can shift more investment in R&D, product design, or advertising, instead of competing with others in improving productivity.

About Zhanghua

Wuxi Zhanghua Pharmaceutical Equipment Co.,Ltd was founded in 1976, committed to researching, developing and manufacturing reaction, crystallization, filtration, drying equipment. With the development of the leading technologies for more than 40 years, our engineering equipment is not only for the pharmaceutical industry, but also for fine chemicals, pesticides, new energy, new materials and other industries. We customize the integrated solution of reaction, crystallization, filtration and drying process equipment for clients. Large CNC vertical lathe and boring machine equipped allows us to customize agitated nutsche filter dryers with diameter of more than four meters, coupled with imported welding robot, which improves the welding accuracy, appearance and quality, as well as safety of the whole equipment. Our technical team is composed of engineers in various fields, including quality assurance, process, equipment, welding, and electrics, and most of them have working experience and engineering project experience of more than ten years. For inflammable, explosive, toxic and corrosive products in pharmaceutical, fine chemical, pesticide, and new energy industries, we will provide customized technical solutions to clients with well-sealed, high vacuum and fully automatic equipment, ensuring safe, energy saving and environment protecting production process, compliance with EHS requirements. Besides, we will help clients to optimize technical designs for high-quality products. All our equipment has met requirements of FDA, CGMP, ATEX and ASME, certified by PED, MD, LVD, MOM and CE as well. As our equipment has already been sold to quite a few pharmaceutical and chemical enterprises in Asia and Europe, our engineers in after-sales service department have rich experience of working abroad. Adhering to professionalism, integrity, innovation and harmony, Wuxi Zhanghua is committed to becoming an advanced global company with high technology and high quality trusted by all the clients. Zhanghua holds more than ten patents and software copyrights, showing its sustainable development and innovation. Through years of efforts, Zhanghua has made considerable progress in reaction, crystallization, filtration and drying technology applied on the equipment in the pharmaceutical, chemical and other industries with good reputation.

Figure 3--- Filter Medium Structure of Conical Filter Dryer 

(2) Small nominal thickness of the filter cake: There are many studies on filtration theory. Due to the large difference in the properties of material particles, there are many factors that affect the filtration rate. with the correct selection of filter medium, the filter cake layer should be formed and play a stable bridging role within a reasonable time to improve the filtration performance. The thinner the filter cake layer is, the faster the filtration speed is.

 

 (3) In the Conical Filter Dryer, the distance between the filter medium and the stirring mechanism is the nominal thickness of the filter cake. The ribbon-type stirring mechanism continuously change the inner cake, the thin layer of filter cake retained on the surface of the filter medium will form a stable filter strengthening layer. At the same time, the replacement process can also smooth the gaps in the filter cake, creating a stable pressure difference, thereby obtaining a filter cake with a lower moisture content.

 

2.2.2 Efficient Washing

 

The internal ribbon-type stirring mechanism of Conical Filter Dryer can quickly repulp the material after adding an appropriate amount of washing liquid. The thorough contact between the filter cake and the washing liquid will greatly improve the washing and replacement efficiency. Compared with the general blade-type and anchor-type stirring mechanism, the ribbon-type one obviously has better repulping performance.

 

2.2.3 Large heat transfer area and efficient drying

 

The Conical Filter Dryer has a large heat transfer area, including the heat transfer area of the main body (equipped with a high-efficiency heat transfer jacket) and the internal overall stirring heat transfer area. The super large heat exchange area not only ensures its drying performance, but more importantly, it makes effective use of the heat exchange area. The exchange contact between the material and the heat exchange parts is the most critical factor.

 

2.3 Automation and real-time monitoring

 

In the process of large-scale pharmaceutical production, if the operation process of a single device is manually controlled, there will inevitably be some errors. In order to ensure the consistency of products between batches in terms of process flow, the Conical Filter Dryer can be controlled automatically, easy to operate and integrate into the central control system (PLC or DCS, etc.), which greatly reduces the labors for equipment operation, improves production efficiency, and effectively guarantees the high quality and stability and products.

 

In addition, it is also very important to monitor the product status inside the equipment for the control of the process flow. The sampler equipped inside can operate online in vacuum during the drying process to ensure continuity of production and effectively monitor the drying performance.

 

2.4 Multi-directional CIP

 

For the Conical Filter Dryer to produce APIs, the internal part in direct contact with the material is polished, and its roughness is Ra≤0.4 μm. After the completion of a batch of products, discharge will be carried out. As the bottom of the equipment is designed as conical, the discharge port is set at the lowest position, no dead corner for accumulated material. After the discharge valve is opened, most of the materials in the forward rotation mixing mechanism will be discharged smoothly (in order to avoid the uncontrolled mass discharge of materials once the valve is opened, the stirring mechanism plays a certain bridging role, and once the material is rotated, it will be automatically discharged by gravity); At the later stage of discharging, the reverse rotation of the stirring mechanism further plays a role in pushing the material, which can almost discharge the remaining material in the equipment.

3 Conclusion

 

The Conical Filter Dryer was born to meet the market demand and has obtained a number of national patents. It has been developed and applied for more than 20 years, and the clean-grade cone-shaped version for the compliance of API production is already the fifth-generation, which closely follows the corresponding regulatory requirements of the pharmaceutical industry, from structural design to application, and has been used in pharmaceutical companies for more than 10 years. With the increasing environmental awareness and the expanding API market, it is essential to upgrade the pharmaceutical equipment. The Conical Filter Dryer will significantly improve product quality, protect the production environment, and bring considerable benefits to the enterprises.

 






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