Process optimization equipment for cefotaxime sodium conical filter washing and drying three-in-one

Process optimization equipment for cefotaxime sodium conical filter washing and drying three-in-one

Since the 1970s, cephalosporin antibiotics are the antibiotics with the fastest development speed and the most varieties on the market. The development of cephalosporin antibiotics in our country was deeply researched after the 1980s, and with its rapid development momentum, it has reached a relatively high level at present. The advantages of cefotaxime sodium, such as wide antibacterial spectrum, good curative effect, low allergy rate and stability to β-lactamase, have been well received by patients, and currently occupy an important position in clinical practice.

Cefotaxime Sodium product use 1. Mainly used for the treatment of respiratory system, urinary system, intestinal tract and biliary tract, skin and soft tissue, burns and bone and joint infections caused by sensitive bacteria 2. Third-generation broad-spectrum cephalosporin antibiotics , It has a strong bactericidal effect on both Gram-negative bacteria and positive bacteria, especially on Gram-negative bacteria. It is stable to β-lactamase and must be administered by injection. It is clinically used for respiratory system infection, urinary system infection, biliary tract and intestinal infection, skin and soft tissue infection, sepsis, burn and bone and joint infection caused by sensitive bacteria.

In the process of industrial production, the technology of cefotaxime sodium is mainly composed of 7-aminocephalosporanic acid and 2-methoxyimino-2-(2-amino-4-thiazolyl)-(z)-benzothiazolylthioate In solvents such as dichloromethane or 2-methyltetrahydrofuran, organic alcohols and other solvents are added, and organic bases are used to catalyze the synthesis of cefotaxime acid. Acidify and crystallize in the organic phase, and centrifuge to obtain a completely dried cefotaxime acid solid.

Afterwards, the dried solid pure product is formed into a sodium salt in an aqueous solution containing sodium acetate or an organic solvent of sodium isooctanoate, and then crystallized with solvents such as acetone or isopropanol to obtain cefotaxime sodium. But adopt existing preparation method often to have following problem:

1. During the reaction process, the problem of oxidative degradation is prone to occur, resulting in the result of more impurities in the product.

2. Due to the existence of impurities and other reasons, the product has a high color grade, which is not conducive to subsequent production, research and utilization.

In order to solve various equipment problems encountered by enterprises in the industrial production of cefotaxime sodium, Wuxi ZhangHua mechanical engineer combined with foreign advanced production technology and excellent technology, after a lot of experiments, finally successfully developed and produced a conical filter washing and drying three-in-one One, and obtained a patent. (Invention patent number: ZL201721560677.6) Conical filtration, washing and drying three-in-one was launched, successfully realized the process optimization of cefotaxime sodium, improved product quality, and created more value for customers.

Cefotaxime Sodium Process Optimization Equipment Conical Filtration Washing Drying Three-in-one Process Flow

Use cefotaxime acid as the raw material, dissolve in the dissolution tank, and enter the crystallization tank after sterilization and filtration for crystallization, filter, wash and pre-dry in the three-in-one barrel-cone type, double-cone (or disc, single-cone) After being dried in a desiccator, it is put into a container for powder mixing, pulverization and sub-packaging to obtain sterile cefotaxime sodium raw material powder.

1. Stirring reaction: This machine is a barrel-cone structure, which can heat or cool the material in the machine for constant temperature and timing reaction;

2. Pressure filtration or vacuum filtration: After the reaction is completed, filter the filtrate through pressure filtration or vacuum suction filtration. In the filtration stage, due to the good adhesion between the ribbon and the filter medium and the scraping effect, the material can be kept in the thin layer of filter cake Filtration under the best conditions, high filtration efficiency;

3. Can be washed and filtered multiple times: After filtering and drying the material, you can add washing liquid, and perform multiple automatic reactions and mixing with the material in the machine before washing, and then filter and dry after washing and filtering meet the washing requirements.

4. Vacuum drying and discharging: After the material is filtered and dried, the material is heated at the same time in the jacket of the drying section, the hollow shaft and the spiral belt, and the vacuum is vacuumed at the top to dry the material in vacuum and low temperature, and it is automatically sealed after drying. Discharge.

Process optimization equipment for cefotaxime sodium Conical filtration washing and drying three-in-one Features and advantages

1. One machine with multiple functions, can complete various operations such as cefotaxime sodium reaction, extraction, filtration, repeated filtration, washing, drying, etc. in one machine, and directly obtain the finished product.

2. Airtight operation, especially suitable for handling flammable, explosive, poisonous or highly toxic dangerous products and delicious food, biological products and medicines that are not allowed to be polluted.

3. The cylinder jacket, cone jacket, hollow shaft, and hollow spiral belt heat or cool the material at the same time, with high thermal efficiency and low energy consumption.

4. The special stirring screw design can make the material be stirred evenly in each stage of reaction, filtration, washing and drying, so that the working efficiency of the whole machine is very high.

5. In the filtration stage, due to the good adhesion and scraping effect of the ribbon and the filter medium, the material can be filtered under the condition of a thin layer of filter cake, and the filtration efficiency is high.

6. Simplify and shorten the technological process, occupy a small area, and greatly save the investment in workshops and equipment.

7. The operation is convenient, the labor intensity is low, and the processed products are of good quality.

Cefotaxime Sodium Process Optimization Equipment Conical Filtration Washing Drying Three-in-one Technical Parameters