At present, the preparation method of high-purity cephalosporin bulk drug cefodizime sodium generally adopts the solvent method process, and the specific steps are:
(1) Sodium isooctanoate is dissolved in ethanol solution to obtain the ethanol solution of sodium isooctanoate;
(2) At 0-30°C, add ethanol, cefodizime acid, and triethylamine, mix and stir to dissolve, decolorize, and obtain cefodizime acid solution;
(3) Mix the above-mentioned ethanol solution of sodium isosulfate with the solution of cefodizime acid to separate out the solid of cefodizime sodium.
(4) Wash the filter cake with absolute ethanol and acetone, and filter with suction to obtain the wet material of cefodizime sodium; filter and dry.
However, in the long-term production practice, it was found that the prepared cefodizime sodium existed: the particles were relatively small and powdery; the static electricity was large, the fluidity was not good, and it was difficult to pack when making reagents; and the ethanol residue was large.
The process still needs further improvement.