The role and significance of the fully enclosed crystallization, filtration, washing and drying machine for the production of hormone pharmaceutical intermediates

As a pharmaceutical intermediate for the synthesis of steroid hormones and steroidal contraceptives, dioscin can also be processed into more than 180 kinds of drugs such as various hormones, analgesics, anesthesia, and contraception. The traditional treatment process is: hydrolysis of hormone pharmaceutical intermediates → solvent extraction → crystallization → centrifugal drying → heating and drying → storage of finished products. The above process is carried out in an open system except that the solvent extraction process is carried out in a closed container, and the centrifugal drying and drying are all carried out in an open system.

The machine used is a three-legged centrifugal dryer and a drying room (fully open). There are major hidden dangers in this process. Solvent volatilization cannot be recovered, and the waste is large. Workers are in direct contact with the solvent, which will cause great damage to the workers.

Design requirements for a fully enclosed crystallization, filtration, washing and drying machine for hormone pharmaceutical intermediates
In order to solve the defects in the production of traditional hormone pharmaceutical intermediates, many pharmaceutical factories adopt the new technology of fully enclosed solvent extraction, and urgently need a solvent-based crystallization, filtration, washing and drying machine that meets the production process requirements, so that it can greatly improve the working environment. Improve the use efficiency of solvent oil and optimize the process flow.

In order to achieve the above purpose, Wuxi ZhangHua Machinery has designed and developed a four-in-one multifunctional equipment for crystallization, filtration, washing and drying. It is characterized in that the cylinder is equipped with a spiral agitator and a filter screen along the axial direction. The agitator is placed in the filter screen. There is a gap, the upper cylinder of the filter net is provided with a feed inlet, and the lower cylinder of the filter net is provided with a liquid outlet, and the liquid outlet is located at the bottom of the conical discharge hopper.

The side wall of the cylinder of the new fully enclosed crystallization, filtration, washing and drying machine is equipped with a jacket that can pass through steam or cooling water. The spiral agitator is composed of a rotating shaft and a helical blade fixed on the rotating shaft. The power mechanism at the top of the cylinder is driven, and the outer edge of the spiral blade is equipped with a scraper near the inner wall of the filter screen, and the cylinder is also provided with a vacuum bag filter connected with a vacuum device.

The crystallization liquid of the extracted hormone pharmaceutical intermediate enters the filter screen in the cylinder body from the feed port on the upper part of the cylinder, and the solvent is filtered out from the filter screen, assuming that the liquid outlet on the cylinder body at the lower part of the filter screen enters the solvent oil storage tank After storage, the crystals are squeezed by a screw agitator to squeeze out the solvent remaining in the crystals for recycling, and the crystals are squeezed out from the discharge port at the bottom of the conical discharge.

The fully enclosed crystallization, filtration, washing and drying machine has a simple structure and is easy to use. The jacket on the cylinder can be heated by steam or cooled by circulating water; the spiral agitator in the cylinder can rotate forward or Reversed, to turn and squeeze the crystals; when the machine is working, the vacuum device can be started, and the vacuum machine can be used to evacuate the cylinder to operate under negative pressure, and the solvent squeezed out of the crystals can be pumped out. Vacuum out and recover for reuse, then the crystallization is dried under vacuum.

The structure and operation instructions of the four-in-one multi-functional equipment
1. Crystallization, filtration, washing and drying four-in-one includes a cylinder, the lower part of which is a conical discharge hopper, which is characterized in that a spiral stirring device and a filter screen are installed in the axial direction of the simplified body, and the spiral stirring device is placed In the filter screen, the filter screen is a cylindrical structure with both ends open. It is coaxial with the spiral stirring device and has a gap with the inner wall of the cylinder. There is a feeding port on the cylinder above the filter screen. There is a liquid outlet on the cylinder at the lower part of the screen, and the outlet is located at the bottom of the conical discharge hopper.

2. The four-in-one multifunctional crystallization filter is equipped with a jacket on the side wall of the cylinder that can pass steam into liquid.

3. The barrel-cone crystallization filter washing and drying machine is a spiral stirring device composed of a rotating shaft and a helical blade fixed on the rotating shaft, and the rotating shaft is driven by a power mechanism located at the top of the barrel.

4. The all-in-one crystallization, filtration and drying machine is equipped with a scraper on the outer edge of the spiral blade close to the inner wall of the filter screen, and a stirring rod is connected to the lower end of the rotating shaft, and the stirring rod is located in the conical discharge hopper.

5. The solvent-type vacuum filtration and drying device is equipped with a vacuum hole connected to the vacuum device on the cylinder body.

From the actual operation and use of the fully enclosed crystallization, filtration, washing and drying machine to process various hormone pharmaceutical intermediates, it can be found that the four-in-one multi-functional equipment has many advantages, the main performances are as follows:
1. One machine is multi-purpose, and it can complete various operations such as reaction, extraction, filtration, repeated filtration, washing, and drying in one machine, and directly obtain the finished product.

2. The operation is flexible, and the operation cycle can be adjusted by adjusting the filter pressure difference, rotation speed, screw extrusion lead, etc., so as to adapt to the change of process conditions.

3. The machine can form a very thin filter cake on the surface of the filter medium or filter under the condition of no filter cake. The filtration rate per unit filter area is very high, so the equipment is small and compact.

4. Fully enclosed system, the operating environment is quite good, especially suitable for handling toxic, flammable, explosive dangerous products and delicious food, biological products and pharmaceuticals that are not allowed to be polluted.

5. It can be concentrated and filtered. Especially when it is necessary to wash the material, the material can be concentrated first, washed thoroughly in the suspension state, and finally press-filtered, which can reduce the handling of the material, reduce waste, and do not need to be repulped during washing. The product quality is very high.

6. It can be used for three operations of reaction, filtration, and drying, so that the functions of the three unit equipment can be completed on this one equipment, so that the equipment cost, floor area, labor intensity, energy consumption, etc. are greatly reduced.

7. The power consumption of this machine is low, and the extruded filter cake generally has lower water content than the flat three-in-one machine, and the operation is also convenient.

Wuxi ZhangHua Machinery has designed a new type of fully enclosed crystallization, filtration, washing and drying machine based on the traditional hormone pharmaceutical intermediates using organic solvent extraction technology, which can greatly improve the working environment and increase the recovery rate of solvents.

The four-in-one multi-functional equipment simplifies the technological process and solves the pollution problem of multiple turnovers caused by multiple processes of drying, washing and drying in the traditional process. The device is not only applicable to the drying of solvent-based crystals, but also practical for the production of fine particles of raw drug crystals, has strong practical value, and is worthy of popularization and application.