The role of filter washing and drying three-in-one in the preparation of water-soluble vitamin E succinate

2023/04/18

Vitamin E succinate has been widely used in developed countries such as Europe, America and Japan. The vitamin E used in almost all tablet and capsule nutritional supplements is vitamin E succinate and calcium succinate, and vitamin E succinate The inhibitory effect of the ester on the growth of human cultured tumor cells is very obvious.



1. Promote the absorption of VA and fat, improve the nutrient supply of the body, enhance the absorption and utilization of nutrients by muscle cells and other biological characteristics.

2. It can effectively delay aging. At the same time, due to its promoting effect on nucleic acid metabolism, it can effectively eliminate oxygen free radicals in the body, maintain the vigorous function of various organs, and play the role of delaying aging and prolonging life.

3. It can prevent and treat muscle atrophy caused by VE deficiency, cardiovascular and cerebrovascular diseases, infertility and miscarriage.

4. It has a very good effect on menopausal disorders, autonomic disorders and high cholesterol, and can prevent anemia and effectively defend life.

5. In VE health care medicines, vitamin E succinic acid not only has the physiologically active function of natural vitamin E, but also has the same high stability as vitamin E acetate, and has a unique anti-cancer health care function and immune regulation function. It has become the most common material for VE drugs and health food drugs for the prevention and treatment of tumors.


Water Soluble Vitamin E Succinate Filtration Washing 3-in-1 Equipment Overview and Working Principle

Filtration washing and drying machine (commonly known as "three-in-one" in the industry) can realize continuous processes such as filtration, washing, drying, sterilization, and unloading of materials. Its operation mode belongs to batch operation (intermittent operation), and is widely used in pharmaceuticals. , food, pesticide, chemical and other fields, can avoid material loss, pollution and environmental pollution that may be caused during the transfer of materials. The existing three-in-one structure is a flat plate type, but some defects have been found in long-term production and use, such as: small circular flat bottom filter area; side discharge, resulting in incomplete discharge; unsatisfactory drying effect, and material turning during the drying process Small, low heat transfer efficiency, limited drying effect, etc.


In order to overcome the problems and deficiencies in the above-mentioned combination of unit equipment, and at the same time meet the transformation of the chemical industry to high quality, high value-added, multi-variety, and small batches, our company has carried out a lot of design and development work, and finally successfully developed the set filter, The multi-functional barrel-cone reaction filter dryer integrating washing and drying has successfully applied for a patent, which has achieved a major improvement in the technical performance of the equipment. From structural design to application, it closely follows the corresponding regulatory requirements of the pharmaceutical industry.

The equipment has three main functions of filtering, washing and drying, and also has many functions such as reaction, extraction, crystallization, concentration, evaporation, mixing and crushing, which belongs to the improved multifunctional equipment.


The new filter washing and drying machine has a barrel-cone structure. There are heating jackets on the cylinder body and the lower cone body to heat or cool the materials. There are hollow shafts and variable-angle variable-lead hollow shafts inside the multi-function machine. The spiral stirring device stirs, stirs and lifts the material, and pushes out the material when discharging. A conical filtering device with a relatively complex structure is installed in the lower cone, and a specially designed non-dead angle quick-opening discharge device or a non-dead angle pneumatic discharge ball valve is installed at the bottom of the equipment.






Water Soluble Vitamin E Succinate Technical Advantages

(1) The production process is fully enclosed

Fully enclosed production process from the beginning of crystallization to the end of drying. This set of equipment is a fully enclosed operating system. The production process is more in line with GMP requirements and specifications, eliminating dust volatilization factors,

Foreign matter contamination is controlled and the risk of microbial contamination is reduced.

(2) Safe and secure

The use of a filter washer-dryer instead of a centrifuge to filter the filter eliminates the safety risk of the centrifuge. The filter washing and drying machine can be filled with nitrogen for protection during the filtration process, and the safety risk is extremely low.

Due to the fully enclosed operation of this production system, it can completely avoid the pollution of the solvent in the production process to the air of the operating environment, and at the same time reduce the occurrence of poisoning accidents caused by contact with toxic substances.

This advantage is even more important today when the voice of safety and occupational health is getting higher and higher.

(3) more environmentally friendly

Because the entire production system is a fully closed system operation, materials and solvents can be recovered almost 100% completely, avoiding waste caused by material omission, legacy and solvent volatilization,

It has great economic benefits, especially when the value of processing materials and using solvents is high.

(4) Simple operation and high degree of automation

Each process is carried out in stages, and the safety measures are complete. The operators can complete the operation after simple training, and the labor intensity is greatly reduced.

(5) Product quality improvement

Because this equipment can re-stir and suspend the filter cake during the washing operation, the impurities in the filter cake can be cleaned, which is conducive to improving product quality.

(6) All operations can be performed using the same system

Filtration, washing, and drying can be completed in the same system, and the workshop space has been utilized to a greater extent. In the era when every inch of land is expensive, reducing the floor space can save a lot of capital investment.

(7) Cleaner production

The filter washing and drying machine can operate in a closed manner, and is equipped with a dust collector to completely collect the dust generated after drying, which can meet the production operation requirements of high cleanliness.

(8) Realize online cleaning

The filter washing and drying machine is equipped with a spray ball, which can easily realize online cleaning operation. Compared with traditional equipment, it can reduce solvent volatilization and safety risks during cleaning.



Wuxi ZhangHua Machinery takes "development and promotion of new high-end equipment and devices that can meet the production of raw materials, especially sterile raw materials, and the overall process equipment system plan" as the company's development direction and goal! In this way, it is ZhangHua's corporate mission to change the production mode of manual operation and material exposure operation of domestic API manufacturers, and to shorten the gap in production equipment technology between my country and advanced countries!


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