Traditional Chinese medicine pills refer to spherical or quasi-spherical preparations made of fine powder or extracts of decoction pieces plus suitable binders or other auxiliary materials. . Traditional Chinese medicine pills began in the pre-Qin period and extended to modern times. They are traditional and classic dosage forms with Chinese characteristics. The drug dosage forms recorded in the earlier medical prescription collection "Fifty-two Disease Prescriptions" in my country are commonly used pills. A total of 1 358 kinds of pills were included in the Chinese Pharmacopoeia, and the first part of the 2015 edition of the "Chinese Pharmacopoeia" included a total of 1 493 kinds of unit medicines and traditional Chinese medicine preparations, of which 466 kinds were pills, accounting for about 31.21%. It is characterized by long-lasting and mild drug effect, which can slow down the volatilization of drugs or mask odors, and prevent oxidation, deterioration, and moisture; for toxic and irritating drugs, the toxicity and adverse reactions can be reduced by delaying the absorption.
The quality evaluation and control of traditional Chinese medicine preparations are hot spots and difficulties in the field of traditional Chinese medicine research, and their quality plays a decisive role in the quality of finished Chinese medicine pills. However, there are many factors affecting the quality of traditional Chinese medicine pills in the preparation process of pills, such as the nature of the powder, the type of binder, the method of preparing pills, pharmaceutical equipment, preparation technology, drying and quality standards, which also directly affect the quality of the finished pills. Dryness is an important factor affecting the effectiveness and safety of pills.
Analysis on the Current Situation of Drying of Traditional Chinese Medicine Pills
Drying refers to the process in which the moisture in the material is removed by heating. The drying degree and speed are affected by factors such as temperature, time, drying equipment and process, and the structure of the material itself. The efficiency of heat and mass transfer in the drying process of Chinese medicine pills ultimately affects Formation of dry mass of pellets.
If the moisture migration inside the pill and the evaporation rate of the boundary layer are asymmetrical during the drying process, it will lead to a long drying cycle of the pill, loss of ingredients, cracked pills, crusts, false drying, yin and yang surfaces, etc.
The drying equipment and technology are closely related to the quality of the pills. The selection of drying equipment and technology should meet the requirements of the quality of the pills. Taking the quality of the pills as the service concept, fully consider the necessity and rationality of optimizing the production process to adapt to the production equipment. Different drying equipment and processes have different characteristics, which will affect the properties, quality, stability and safety of drugs.
The quality of pills is closely related to drying. The selection of drying equipment and process is very important, and the control of drying process conditions cannot be ignored, which directly affects the quality of pills and whether the quality standards meet the requirements of the Pharmacopoeia.
Through the actual investigation of many pharmaceutical companies across the country, it is found that there are many problems in the production of traditional Chinese medicine pills. ①The drying cycle is long, and the drying time of traditional Chinese medicine pills is generally more than 9 hours, and some varieties even exceed 24 hours; ②The high temperature leads to a large loss of aromatic components and heat-sensitive components, and the curative effect of the drug is reduced; ③The drying process is backward and the equipment lacks innovation. , mainly using van static drying with extensive process control; ④ high energy consumption for drying and low heat utilization rate; ⑤ low level of quality control, lack of systematic methods and evaluation methods for pill quality evaluation;
There are many aspects of incompatibility in the equipment of traditional Chinese medicine pills. The traditional drying equipment has simple structure, extensive process, high energy consumption and low cost, but it does not meet the requirements of GMP and is gradually eliminated. However, the new pill drying equipment developed by some new technologies cannot cope with large-scale industrial production applications due to factors such as immature technology, complex equipment and high cost. Drying equipment and technology will affect the quality of traditional Chinese medicine pills, and then affect their efficacy.
The drying equipment and process are closely related to the quality of the pills. Different types of traditional Chinese medicine pills have different characteristics, and the requirements for the drying process and equipment are also different. The selection of drying equipment and processes should meet the requirements of the quality of the pills. The quality of the pills is the basis. The service concept fully considers the necessity and rationality of optimizing the production process in order to adapt to the production equipment. Under the premise of ensuring that the active ingredients of traditional Chinese medicine pills are not lost, the drying equipment and process should also be efficient and energy-saving, so as to better ensure the quality and related qualities of traditional Chinese medicine pills. Wuxi ZhangHua Machinery Co., Ltd. has carried out a lot of design and development work, and finally successfully developed a multifunctional cylinder-cone reaction filter dryer integrating filtration, washing and drying, and successfully applied for a patent (patent number: ZL201721560677.6.), It has achieved a great improvement in the technical performance of the equipment, and closely followed the corresponding regulatory requirements of the pharmaceutical industry from structural design to application.
The equipment has three main functions of filtering, washing and drying, and also has many functions such as reaction, extraction, crystallization, concentration, evaporation, mixing and crushing, which belongs to the improved multifunctional equipment.
CGMP traditional Chinese medicine pill drying equipment Conical three-in-one vacuum dryer is especially suitable for drying flake, strip and granular materials with good air permeability. The traditional belt dryer has one or more drying chambers, and the conveyor belt carries materials through all the drying chambers. Each drying chamber is equipped with a heat exchanger, and the hot air flows through the conveyor belt from top to bottom or from bottom to top. material, so that the material can be dried evenly.
For the belt dryer with the heating device installed in the drying chamber, for the materials that are prone to dust during the drying process, the dust is easy to deposit on the surface of the heat exchanger, which affects the efficiency of the heat exchanger. The device is generally finned, which is difficult to clean thoroughly, and there are residues. The same equipment is used to dry different materials, which will cause cross-contamination of new materials.
About ZhangHua CGMP traditional Chinese medicine pill drying equipment conical three-in-one vacuum dryer, you can get more product information and experience one-stop customized service through the following contact information.