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New patented equipment for the production of anti-tumor raw material sodium polyglutamate, drum-cone filter, washing and drying machine

2023/04/14

Polyglutamic acid (γ-pga), also known as natto gum and polyglutamic acid, is a water-soluble, biodegradable, non-toxic biopolymer produced by microbial fermentation. Polyglutamic acid is widely used in medicine, mainly as a slow-release targeting carrier of drugs and a carrier of external drugs. Polyglutamic acid is a biodegradable polymer, and its degradation products can be absorbed and utilized by the body or excreted through normal metabolism. It is mainly used for drug release and delivery carriers and non-permanent implant devices. In addition to meeting general physical and chemical performance requirements, it can also meet biocompatibility requirements.



In recent years, due to the enhancement of people's environmental awareness and the requirements of the national sustainable development strategy, the development of environmentally friendly materials and the development of products that improve environmental problems have become an industrial trend, which also promotes the industrialization of polyglutamic acid research and the process of exploration. In this century, a few well-known international companies have begun to conduct research on the production and application of polyglutamic acid, and some domestic universities and research institutes have also actively carried out related research, and several domestic companies have begun to plan large-scale production of polyglutamic acid . Due to the follow-up of these industrialization studies, polyglutamic acid has become one of the most concerned biological products at this stage.



Extraction and production process of traditional polyglutamic acid
1. Traditional peptide synthesis method The traditional peptide synthesis method is to connect amino acids one by one to form a polypeptide. This process generally includes group protection, reactant activation, coupling and deprotection. Chemical synthesis is an important method for peptide synthesis, but the synthetic route is long, with many by-products and low yield, especially for the synthesis of pure peptides containing more than 20 amino acids.


2. In the early days, most of the Japanese production of γ-polyglutamic acid used the extraction method to separate and extract PGA from natto (a traditional Japanese food) with ethanol.

Because the concentration of gamma polyglutamic acid contained in natto is very small and fluctuates, the extraction process is very complicated, the production cost is very high, and it is also difficult to produce on a large scale.


New patented equipment for the production of sodium polyglutamate, barrel-cone filter, washing and drying machine, process characteristics

Sodium polyglutamate needs to keep the environment dry during the production process, but the existing drying equipment is inconvenient to disassemble, so Wuxi ZhangHua Machinery Co., Ltd. has carried out a lot of design and development work, and finally successfully developed a filter, washing, drying machine. The integrated multi-functional cylinder-cone reaction filter dryer has successfully applied for a patent (patent number: ZL201721560677.6.), which has greatly improved the technical performance of the equipment. From structural design to application, it closely follows the corresponding regulatory requirements of the pharmaceutical industry. . The equipment has three main functions of filtration, washing and drying, and also has many functions such as reaction, extraction, crystallization, concentration, evaporation, mixing and crushing. It belongs to high-tech equipment and has the following advantages:
1. One machine is multi-purpose, and can complete various operations such as reaction, extraction, filtration, repeated filtration, washing, and drying in one machine, and the finished product can be obtained directly.


2. Airtight operation, especially suitable for handling flammable, explosive, poisonous or highly toxic dangerous products and delicious food, biological products and medicines that are not allowed to be polluted.
3. The cylinder jacket, cone jacket, hollow shaft, and hollow spiral belt heat or cool the material at the same time, with high thermal efficiency and low energy consumption.
4. The special stirring screw design can make the material be stirred evenly in each stage of reaction, filtration, washing and drying, so that the working efficiency of the whole machine is very high.


5. In the filtration stage, due to the good adhesion and scraping effect of the ribbon and the filter medium, the material can be filtered under the condition of a thin layer of filter cake, and the filtration efficiency is high.
6. Simplify and shorten the technological process, occupy a small area, and greatly save the investment in workshops and equipment.

7. The operation is convenient, the labor intensity is low, and the processed products are of good quality.


New patented equipment for the production of sodium polyglutamate, barrel-cone filter, washing and drying machine process flow
1. Stirring reaction: This machine is a barrel-cone structure, which can heat or cool the material in the machine for constant temperature and timing reaction;
2. Pressure filtration or vacuum filtration: After the reaction is completed, filter the filtrate through pressure filtration or vacuum suction filtration. In the filtration stage, due to the good adhesion between the ribbon and the filter medium and the scraping effect, the material can be kept in the thin layer of filter cake Filtration under the best conditions, high filtration efficiency;
3. Can be washed and filtered multiple times: After filtering and drying the material, you can add washing liquid, and perform multiple automatic reactions and mixing with the material in the machine before washing, and then filter and dry after washing and filtering meet the washing requirements.
4. Vacuum drying and discharging: After the material is filtered and dried, the material is heated at the same time in the jacket of the drying section, the hollow shaft and the spiral belt, and the vacuum is vacuumed at the top to dry the material in vacuum and low temperature, and it is automatically sealed after drying. Discharge.

New patented equipment for the production of sodium polyglutamate, barrel-cone filter, washing and drying all-in-one machine, working principle


The new filter washing and drying machine has a barrel-cone structure. There are heating jackets on the cylinder body and the lower cone body to heat or cool the materials. There are hollow shafts and variable-angle variable-lead hollow shafts inside the multi-function machine. The spiral stirring device stirs, stirs and lifts the material, and pushes out the material when discharging.

A conical filtering device with a relatively complex structure is installed in the lower cone, and a specially designed non-dead angle quick-opening discharge device or a non-dead angle pneumatic discharge ball valve is installed at the bottom of the equipment.


In the reaction stage, the reaction materials are added from the top, and the unique stirring structure can make the materials be stirred evenly in the machine, and the materials are heated or cooled simultaneously through the cylinder jacket, cone jacket, hollow shaft, and hollow spiral blade. Make the material fully react in the machine. In the filtration stage, the machine can filter and dry the material in the machine by pressurizing or vacuuming, and add washing liquid, so that the material can be automatically repulped and washed several times in the machine, and then pressed dry after meeting the washing requirements.

In the drying stage, the cylinder jacket, cone jacket, hollow shaft, and hollow ribbon heat the material at the same time and vacuumize the top, vacuum-tight and low-temperature drying of the material, and automatically seal and discharge the material after drying.



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